Eosinophilic Esophagitis: Translational Approaches to Diagnostic and Therapeutic Challenges

Dr. Amanda Muir is a pediatric gastroenterologist at the Children’s Hospital of Philadelphia, where she is an Assistant Professor of Pediatrics. She earned a BA in Biology from Amherst College and then attending Rutgers-Robert Wood Johnson Medical School. She completed residency at Children’s Hospital of Philadelphia and stayed on to perform her fellowship in Gastroenterology, Hepatology and Nutrition.  As a post-doctoral fellow, she completed her Masters in Translational Research.  She completed the Consortium of Eosinophilic Gastrointestinal Disease Research Trainee Program.  She is a member of the Center for Pediatric Eosinophilic Disorders which specializes in the care of patients with eosinophilic gastrointestinal disorders including Eosinophilic esophagitis as well as eosinophilic gastritis and enteritis.

The Muir Lab focuses on evaluating mechanisms of epithelial disruption and fibrosis in Eosinophilic esophagitis (EoE). The lab has pioneered a 3D ex vivo primary human organoid model of EoE and they are working on translational approaches to evaluate and treat esophageal fibrosis.  She is the co-founder of the Gastrointestinal Epithelial Modeling Program which is a collaborative research effort designed to accelerate discovery and innovation using patient-derived organoids (PDO).

Learning Objectives:

  1. Understand differences in Eosinophilic esophagitis disease presentation throughout childhood
  2. Discuss the standard diagnostic and therapeutic strategies in Eosinophilic esophagitis
  3. Consider the challenges in detecting and treating patients with esophageal fibrosis from Eosinophilic esophagitis


This seminar was delivered as a Pediatric Grand Rounds Lecture at Children’s Hospital of Philadelphia, on September 21, 2022.

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Course Includes

  • 1 Lesson
  • Course Certificate
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