Does the Shoe Fit? Adult Guideline Directed Medical Therapy (GDMT) and the Failing Pediatric Heart

Dr. Miyamoto is a tenured Professor of pediatrics, the Director of the Cardiomyopathy Program, and the Jack Cooper Millisor Chair in Pediatric Heart Disease at Children’s Hospital Colorado and the University of Colorado Anschutz Medical Campus. As a pediatric cardiologist, her clinical expertise includes the care of infants and children suffering from various forms of cardiomyopathy and heart failure as well as the care of children who have had a heart transplant. Dr. Miyamoto’s research interests include studies of molecular adaptation of the failing pediatric heart, and identification of novel therapeutic targets through mechanistic studies using animal and cellular models. She also participates in clinical trial research and has performed studies of circulating microRNAs as a diagnostic and prognostic biomarker for a wide range of cardiovascular diseases spanning the fetus to the adult. She performs advocacy work and supports research in pediatric heart disease through her involvement with the American Heart Association, the Children’s Cardiomyopathy Foundation, the Children’s Heart Foundation, and Additional Ventures.

Learning Objectives:

  1. Understand pediatric heart failure outcomes in the context of adult heart failure outcomes.
  2. Understand age-specific findings in the pediatric failing heart and how these may have implications for response to existing Adult Guideline Directed Medical Therapy (GDMT)
  3. Learn how clinical trials in pediatric heart failure differ from adult clinical trials


  • Shelley Miyamoto, MD  

This seminar was delivered as a Pediatric Grand Rounds Lecture at Children’s Hospital of Philadelphia, on April 12, 2023.

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Course Includes

  • 1 Lesson
  • Course Certificate
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