Developing Novel Risk Factors in Congenital Heart Disease and Cardiac Arrest

Monique Gardner, MD is an attending physician in the Cardiac Intensive Care Unit at the Children’s Hospital of Philadelphia, and Assistant Professor of Anesthesiology and Critical Care and Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Gardner came to Philadelphia for CHOP pediatrics residency after completing medical school at New York Medical College. She continued her CHOP training as a pediatric cardiology fellow, where she developed an interest in cardiac critical care and the care of infants with critical congenital heart disease. During her cardiology fellowship, she was awarded the Ann Newman Award, recognizing a second-year fellow for clinical excellence. Dr. Gardner then completed her critical care medicine training at the University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh, where she honed her care of children with critical illness, preparing herself for a career in CICU. She was recognized as Fellow of the Year before graduation, nominated by the pediatrics residents. She joined the CHOP CICU faculty in 2019. Dr. Gardner is board certified in pediatrics, pediatric cardiology, and pediatric critical care.

Dr. Gardner’s research focuses on children critically ill from cardiac disease, particularly neonates requiring surgery in the first weeks of life, and children recovering from cardiac arrest. She began her clinical research career as a cardiology fellow studying the impact of home monitoring on infants discharged after neonatal operations for single ventricle congenital heart disease. She has subsequently transitioned to focusing on plasma biomarkers that help identify neonates at risk for poor outcomes after cardiopulmonary bypass surgery and developing novel markers for risk assessment. Dr. Gardner is also exploring risk factors for mortality and neurologic impairment after pediatric cardiac arrest, in children with prior cardiac disease and those without. Given her training in echocardiography, and experience utilizing novel biomarkers, Dr. Gardner is examining the post-cardiac arrest state of inflammation and myocardial dysfunction. Dr. Gardner has published in the Journal of American Heart Association, American Journal of Cardiology, Pediatric Cardiology and Resuscitation.

Learning Objectives:

  1. Identify the benefits of utilizing novel blood biomarkers to identify pre- and post-operative risk for neonates requiring cardiopulmonary bypass
  2. Explain the importance of recognizing post-cardiac arrest myocardial dysfunction and systemic inflammation and their impact on outcomes


This seminar was delivered as a Pediatric Grand Rounds Lecture at Children’s Hospital of Philadelphia, on May 11, 2022.

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Course Includes

  • 1 Lesson
  • Course Certificate
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