CFTR Modulators: Transformative Medicines for Cystic Fibrosis

Clement L. Ren, MD, MBA holds the Richard B. Johnston Jr. Chair in Pediatrics and is a Professor of Pediatrics at the Perelman School of Medicine. He is a member of the Division of Pulmonary and Sleep Medicine and serves as the Cystic Fibrosis Center Director at Children’s Hospital of Philadelphia. Dr. Ren earned an AB in Biophysics from the University of California at Berkeley and an MD from the University of Chicago. He then completed a pediatric residency and allergy/immunology fellowship at Boston Children’s Hospital, followed by a fellowship in pediatric pulmonology at St. Christopher’s Hospital for Children. He also holds an MBA (Medical Management) from the University of Rochester.

Dr. Ren’s research has focused on developing better methods to assess lung disease in children with cystic fibrosis (CF) and bronchopulmonary dysplasia (BPD). The majority of this work has utilized infant/preschool pulmonary function testing, and more recently he is using lung MRI and home-reported outcomes using a phone-based application. His other area of scholarly activity has been CF epidemiology, where he has performed numerous analyses using the CF Foundation Patient Registry and the Epidemiologic Study of CF. In addition to advancing knowledge through research, he has helped advance care through leadership and service in the CF Foundation and American Thoracic Society, where he has chaired and served on committees, been elected as the Pediatric CF Program Directors’ representative, led the development of clinical practice guidelines, and headed quality improvement initiatives. He is an Associate Editor for Pediatric Pulmonology and a member of the American Board of Pediatrics Sub-Board for Pediatric Pulmonology.

Learning Objectives:

  1. Describe the mechanism of action of different CFTR modulators
  2. Describe the side effects of CFTR modulators
  3. Describe the unmet needs in CF care and research in the era of highly effective CFTR modulators


  • Clement L. Ren, MD, MBA

This seminar was delivered as a Pediatric Grand Rounds Lecture at Children’s Hospital of Philadelphia, on September 7, 2022.

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Course Includes

  • 1 Lesson
  • Course Certificate
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